报告一：Effect of Prenatal Obesogen Exposure Echo down the Generation
主讲嘉宾：美国加州大学欧文分校 Bruce Blumberg 教授
报告二：IKKbeta, from inflammation to cardiometabolic disease and beyond
主讲嘉宾：美国肯塔基大学 周长城 教授
时 间：2018年10月30日 10:00-11:30
地 点：护理楼二层多功能厅
主讲嘉宾简介：
Bruce Blumberg教授于加州大学洛杉矶分校获得博士学位。现任加州大学欧文分校发育与细胞生物学、药理学和生物医学工程系教授。Blumberg教授首先克隆了PPARγ、PXR等重要核受体，是国际核受体与内分泌代谢领域著名专家。Blumberg教授研究方向为胚胎发育和生理过程中的基因调控和细胞信号转导。主要集中在核受体在发育、生理和疾病中的作用。Blumberg教授提出了肥胖原假说，该假说认为发育过程中暴露于内分泌干扰物（EDCs）可以诱发永久性生理改变。EDCs暴露可引起基因表达的表观遗传改变，从而使间充质干细胞易于成为脂肪细胞。暴露后的动物尽管正常饮食和运动，但会产生越来越多的脂肪细胞，导致体重增加和肥胖。
Bruce Blumberg, Ph.D.
Bruce Blumberg received his Ph.D. at University of California Los Angeles. He is currently a Professor in Departments of Developmental & Cell Biology, Pharmaceutical Sciences and Biomedical Engineering, University of California Irvine. The Blumberg laboratory is broadly interested in the study of gene regulation and intercellular signaling during embryonic development and physiology. Current research focuses on the role of nuclear hormone receptors in development, physiology and disease. Particular interests include patterning of the vertebrate nervous system, the differential effects of endocrine disrupting chemicals (EDCs) on laboratory model organisms compared with humans, interactions between xenobiotic metabolism, inflammation, and cancer, and the role of environmental endocrine disrupting chemicals on the development of obesity and diabetes.
Dr. Blumberg and his colleagues originated the obesogen hypothesis which holds that developmental exposure to EDCs can induce permanent physiological changes. EDC exposure elicits epigenetic alterations in gene expression that reprograms the fate of mesenchymal stem cells, predisposing them to become fat cells. Exposed animals develop more and larger fat cells, despite normal diet and exercise which is likely to lead to weight gain and obesity over time.
主讲嘉宾简介：
周长城，美国肯塔基大学医学院药理与营养科学系副教授及代谢疾病研究中心主任。1995年、1998年分别获得吉林大学本科和硕士学位，2004年获得加州大学尔湾分校细胞生物学博士，先后在华盛顿大学、洛克菲勒大学进行博士后研究。在Arteriosclerosis Thrombosis and Vascular Biology、Diabetes、Journal of Clinical Investigation、Journal of Biological Chemistry、Journal of Lipid Research、Journal of Experimental Medicine等杂志发表研究论文数十篇。作为独立PI，目前主持美国国家卫生部多项研究基金项目。现为美国心脏协会Fellow（FAHA），担任多种心血管领域杂志的编委，并是美国国家卫生部及心脏协会科研基金评审专家。
Dr. Zhou is an Associate Professor in Pharmacology & Nutritional Sciences, Director of Center for Metabolic Disease Research, University of Kentucky. He graduated from Jilin University majoring in Molecular Biology and received his Ph.D from University of California Irivne. Dr. Zhou completed postdoctoral training at University of Washington and Rockefeller University. Dr. Zhou is interested in the molecular mechanisms of atherosclerosis and metabolic disorders. Research in his lab has been continuously funded by grants from the National Institutes of Health.
